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Epicutis

Epicutis Hydrobiome Serum

Regular price
$275.00
Regular price
Sale price
$275.00
Shipping calculated at checkout.

It's not just a blemish. It's an imbalance.

The Epicutis Hydrobiome Serum is microbiome skincare that works with your skin rather than against it. Instead of stripping or aggressively drying the skin to chase blemishes, it helps rebalance your skin's living ecosystem — calming the look of irritation, supporting the barrier and bringing back a clearer, healthier-looking complexion. Balance your biome, and your skin follows.

Lightweight, fast-absorbing and beautifully minimal at just 10 purposeful ingredients, it pairs two clinically studied actives to balance, calm and strengthen.

Key actives

  • TCP (a patented isoprenyl-cysteine active developed by Signum Biosciences) — supports microbiome balance and helps calm the appearance of irritation, selectively discouraging the bacteria associated with blemishes while preserving the skin's beneficial flora.
  • TPNa (stabilised, water-soluble Vitamin E) — advanced antioxidant protection that helps neutralise oxidative stress, support the skin barrier and reduce the look of redness.
  • Sodium Hyaluronate — boosts hydration and moisture retention.
  • Propanediol — supports a plumped, hydrated feel and helps deliver the formula.

Formulated to help

  • Balance and support the skin microbiome
  • Calm the look of irritation and redness
  • Strengthen and support the skin barrier
  • Reduce the appearance of blemishes

Who it's for

Sensitive, reactive and blemish-prone skin, redness and barrier support, and post-procedure care — gentle enough to use immediately after in-clinic treatments.

How to use

Apply two pumps to clean fingertips and spread evenly over the face until absorbed; add a pump for neck and décolleté. Use morning and night. If layering with the Epicutis Lipid Serum, apply Hydrobiome Serum first (straight after cleansing), then Lipid Serum.

Around treatments: use for 10–14 days before ablative or non-ablative treatments, and it's soothing enough to use immediately afterwards — up to four times daily while redness or post-procedure sensitivity remains.

Details

50 mL / 1.7 fl oz · 10 ingredients · Made in the USA · EWG Verification pending.

Full ingredients: Aqua/Water, Propanediol, Pentylene Glycol, Glycerin, Disodium Tetramethylhexadecenylcysteine Formylprolinate, Sodium Tocopheryl Phosphate, Sodium Hyaluronate, Sodium Phytate, Carbomer, Potassium Hydroxide.

Not sure if it's right for your skin? Book a skin consultation and our team will tailor it to you.

This information is general and cosmetic in nature and not a substitute for personalised skin or medical advice.

Epicutis Hydrobiome Serum
Epicutis Hydrobiome Serum
Hydrobiome Serum before and after results — 4–6 weeks use
Epicutis Hydrobiome Serum — microbiome skincare campaign
PRODUCT INFO

Microbiome skincare that works with your skin, not against it. The Hydrobiome Serum helps rebalance your skin's living ecosystem to calm the look of irritation, support the barrier and bring back a clearer, healthier-looking complexion.

It pairs two clinically studied actives — TCP, a patented active that supports microbiome balance and helps calm visible irritation, and TPNa, a stabilised water-soluble Vitamin E for antioxidant protection and barrier support — with hydrating sodium hyaluronate. Lightweight, fast-absorbing and just 10 purposeful ingredients.

Formulated to help: balance the microbiome · calm the look of irritation and redness · strengthen the skin barrier · reduce the appearance of blemishes.

50 mL / 1.7 fl oz · Made in the USA · EWG Verification pending.

HOW TO USE

Apply two pumps to clean fingertips and spread evenly over the face until absorbed; add a pump for neck and décolleté. Use morning and night.

Layering: if using with the Epicutis Lipid Serum, apply Hydrobiome Serum first (straight after cleansing), then Lipid Serum.

Around treatments: use for 10–14 days before ablative or non-ablative treatments, and it is gentle enough to use immediately afterwards — up to four times daily while redness or post-procedure sensitivity remains.

INGREDIENTS

Aqua/Water, Propanediol, Pentylene Glycol, Glycerin, Disodium Tetramethylhexadecenylcysteine Formylprolinate, Sodium Tocopheryl Phosphate, Sodium Hyaluronate, Sodium Phytate, Carbomer, Potassium Hydroxide

  • PRODUCT INFO
  • HOW TO USE
  • INGREDIENTS

Microbiome skincare that works with your skin, not against it. The Hydrobiome Serum helps rebalance your skin's living ecosystem to calm the look of irritation, support the barrier and bring back a clearer, healthier-looking complexion.

It pairs two clinically studied actives — TCP, a patented active that supports microbiome balance and helps calm visible irritation, and TPNa, a stabilised water-soluble Vitamin E for antioxidant protection and barrier support — with hydrating sodium hyaluronate. Lightweight, fast-absorbing and just 10 purposeful ingredients.

Formulated to help: balance the microbiome · calm the look of irritation and redness · strengthen the skin barrier · reduce the appearance of blemishes.

50 mL / 1.7 fl oz · Made in the USA · EWG Verification pending.

Apply two pumps to clean fingertips and spread evenly over the face until absorbed; add a pump for neck and décolleté. Use morning and night.

Layering: if using with the Epicutis Lipid Serum, apply Hydrobiome Serum first (straight after cleansing), then Lipid Serum.

Around treatments: use for 10–14 days before ablative or non-ablative treatments, and it is gentle enough to use immediately afterwards — up to four times daily while redness or post-procedure sensitivity remains.

Aqua/Water, Propanediol, Pentylene Glycol, Glycerin, Disodium Tetramethylhexadecenylcysteine Formylprolinate, Sodium Tocopheryl Phosphate, Sodium Hyaluronate, Sodium Phytate, Carbomer, Potassium Hydroxide

What Our Clients Say

4.9 from 100 Google reviews

Our family cannot speak highly enough of this beautiful clinic and the incredible team who work there. From the moment you walk in, the environment feels calm, welcoming and professional. The staff combine genuine warmth with impressive expertise, and put both adults and teenagers completely at ease. We have all been consistently thrilled with the results — natural, confidence-boosting and exactly what we hoped for. We trust them completely with our family’s skin health and truly can’t recommend them highly enough.

Chantal Jvia Google

I completed a 12-month bridal skin preparation package to get my skin ready for my wedding, and the results were incredible. My plan included HydraFacials, Laser Genesis, and microneedling, along with Biologique Recherche and SkinCeuticals skincare. Over the year my skin completely transformed — my hyperpigmentation and acne scars significantly improved, and my complexion became clear, smooth and glowing. Cara, Tresa and Ruby are extremely knowledgeable and focused on long-term skin health. I highly recommend to any bride looking for real results.

Anuradha A.via Google

I’ve been coming here for a few months and have had such a wonderful experience. Treasa, Ruby and Cara are an incredibly kind and caring team. Ruby always takes the time to check in on my skin after every treatment and really cares about my progress. Tresa is warm, gentle and very attentive, always making sure I’m comfortable and well looked after. I’ve seen a huge improvement in my skin and I’m so happy with the results. Highly recommend!

Yashu P.via Google

I’ve been going here for years and it’s always a 5-star experience. The team are warm, thoughtful and extremely discreet. They truly listen and I’ve never felt rushed or ‘sold to’. They’ve helped me achieve amazing results and my skin has honestly never looked better. Huge thank you to Cara and the team. Absolute legends!

Kate Byrnevia Google

I’ve been coming to The Clinic: Skin Health for about a year and I could not thank the girls enough for what they have done for my skin! I had tried everything to stop some aggressive and painful acne and within a couple of months it was all gone — not even a scar left! My skin is smooth, clear and glowing every day. The relaxing atmosphere and gentle touch make it the best place to unwind, plus the complimentary head massages are to die for.

Isabelle T.via Google

The entire team at The Clinic are educated and skilled at using their products and methods effectively to assist my mature skin in maintaining a glow, and importantly each therapist is also caring. Thank you team.

Lanette H.via Google

Cara and the team have been absolutely amazing in transforming my skin. I have been going for over 2 years now, and they have been so helpful in managing my rosacea — first in diagnosing and treating it, and now in ongoing maintenance. The team is so knowledgeable and helpful, and my skin has never been better.

Loretta B.via Google

After being told by another skin clinic that nothing could be done about my acne except going on Accutane, I went to The Clinic Skin Health for a second opinion. It’s safe to say it was the best decision I could’ve made. Cara is so knowledgeable and her holistic approach meant no stone was left unturned in uncovering the root cause of my acne. 6 months in, my skin has transformed entirely and is something I take pride in.

Meg F.via Google

I first stumbled upon The Clinic in 2022, when I had all but given up on my skin. Having struggled for years and tried countless treatments, I was resigned to having acne forever. They not only cleared up my skin, but helped me understand my lifestyle and body better. Cara, Treasa and Ruby are incredibly knowledgeable, warm and welcoming. If you are struggling with your skin, I highly recommend reaching out to The Clinic — you will not regret it!

Rachael N.via Google